Investigation of the curative effects of Hypericum perforatum (St. John's Wort) and Rosa spinosissima (Black rosehip) on rats in an indomethacin-induced gastric peptic ulcer model

In this study, histopathological and immunohistochemical evaluations were made on the damage to gastric tissue in peptic ulcer model induced by indomethacin, it was investigated whether plants Hypericum perforatum Rosa spinosissima have a therapeutic effect. order create an model, 25mg/kg indomethacin administered orally rats other groups, except sham control group, 2 doses, 24 hours apart. treatment first dose of given hour after second dose, plant oils later. Then, 1 later, sacrificed. evaluation, sections belonging group showed intense degeneration both epithelial mucosal glands mucosa. Edema bleeding also present lamina propria submucosa layers. These observed damages significantly reduced RS+HP-1 RS+HP-2 groups. As result evaluations, that with highest Bax immunoreactivity groups lowest RS+HP-2. It determined Bcl-2 The results anti-apoptotic effects injury.